Search academic texts

Information × Registration Number 0220U104889, 0120U102510 , R & D reports Title To optimize the diagnosis and to develop methods for non-specific prevention of community-acquired pneumonia caused by coronaviruses or their combination with bacterial pathogens popup.stage_title Head Dziublyk Oleksandr Ya., Доктор медичних наук Registration Date 30-12-2020 Organization State organization "National Institute of Phthisiology and Pulmonology named after F.G. Yanovsky National academy of medical sciences of Ukraine" popup.description2  Object – patients with community-acquired pneumonia of coronavirus etiology of moderate and severe course. Aim – to improve the etiological and clinical-radiological diagnosis and methods of non-specific prevention of community-acquired pneumonia caused by coronaviruses or their combination with bacterial pathogens. Methods – microbiological (virological methods in cell culture), statistical. The cytotoxic effect of decamethoxine in five cell cultures in vitro experiment depends on the type of cell culture. It was found that decamethoxine in cell cultures of CEF and CEFs in vitro showed a pronounced virucidal activity against the reference strain of coronavirus IBV. ). It was found that Decasan showed pronounced virulicide activity in vitro in cultures of CEF and CEFs cells. It was shown that in a dose of 200 μg / ml the agent completely inactivated 100–1000 infectious doses of the virus with a duration of irradiation of 30 min without manifestations of cytotoxic effects in serial dilutions. It was shown that Decasan had a virulicide effect in vitro on the coronavirus (Infection bronchitis virus – IBV) in the transduced culture of cell BNK-21. It was found that in a dose of 1000 μg / ml, the test agent completely inactivated 1000–10000 infectious doses of the virus with a duration of exposure of 30 min. It was developed a method of non-specific (secondary) prevention of community-acquired pneumonia caused by coronaviruses or their combination with bacterial pathogens by using the antiseptic drug decamethoxine, that will reduce the risk of community-acquired pneumonia. Sphere of application – pulmonology. Product Description popup.authors Bororova Olena L Gumenuk Mykola I Denysova Olha V Dziublyk Oleksandr Ya. Kapitan Heorhiy B Mukhin Oleksandr O Patyuk Yuliya O Sukhin Rostyslav Ye Iachnyk Vitalii A popup.nrat_date 2020-12-30 Close