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Information × Registration Number 0221U000123, 0119U102416 , R & D reports Title The functional activity of phagocytic cells as a predictor of the effectiveness of doxorubicin antitumor action popup.stage_title Head Lykhova Olexandra O., Кандидат біологічних наук Registration Date 02-01-2021 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine popup.description2  Both, original and doxorubicin-resistant Walker-256 carcinosarcoma, induce alteration in the peripheral blood counts and peritoneal macrophages’ functional activity in rats. In animals bearing Walker-256 carcinosarcoma (independently whether it is original or doxorubicin resistant), on terminal stages of tumor growth (day 22) erythrocytes count together with hemoglobin levels were decreased while platelets and granulocytes counts were elevated. These changes (p˂0.05 comparing to the intact control) were more apparent in rats bearing doxorubicin-resistant Walker-256 carcinosarcoma cell line. The NO/Arginase ratio, depicting macrophages activity, was slightly decreased (1.1 times comparing with the intact animals) in rats bearing original Walker-256 carcinosarcoma. Growth of the doxorubicin-resistant Walker-256 carcinosarcoma induced more remarkable reduction in NO production and rise in Arginase activity: NO/Arginase ratio was 1.5 (p˂0.05) and 1.3 (p˃0.05) times lower as compared with the intact rats and the rats bearing original cell line, respectively. In terminal stages of Walker-256 carcinosarcoma growth, notable suppression of the macrophages activity together with the deepening of anemia manifestations and significant increase in platelets and granulocytes counts may be considered as the markers of doxorubicin resistance formation. Product Description popup.authors Lykhova Olexandra O. Chumak Alina V. popup.nrat_date 2021-01-02 Close