Search academic texts

Information × Registration Number 0221U000126, 0118U005185 , R & D reports Title Development of 2D-materials and "smart" sensors for medical and biological purposes on their basis. Section 3. 2D-materials based on BN and WS2 as potential antitumor and antimetastatic agents popup.stage_title Head Solianyk Galyna I., Доктор фізико-математичних наук Registration Date 02-01-2021 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine popup.description2  A study of cytotoxic/cytostatic activity of newly synthesized 2D-materials (tungsten disulfide and molybdenum disulfide) in combination with antitumor drug doxorubicin in relation to Lewis lung carcinoma cells (LLC) in vitro was conducted. Samples of tumor cells exposed to 2D nanomaterials were also prepared for further visualization of their position in cells by methods of IR spectroscopy and confocal microscopy. There was no significant increase in the cytotoxic action of doxorubicin in relation to tumor cells due to its combination with 2D materials. To enhance the pharmacological action of the agents studied, the method of modification of existing antitumor agents was used on the basis of the use of ionizing radiation, namely the treatment of their solvents with highly energy electrons. On the example of doxorubicin, it was shown that the preliminary radiation of its solvent (physiological solution) by high energy electrons enhances its cytotoxic effect on tumor cells in vitro, and most pronounced at relatively low concentrations of the drug. The strengthening of pharmacological activity of doxorubicin due to solvent radiation was also confirmed by IC50, which for the drug in the irradiated solvent was lower than in the non-irradiated one, indicating the prospects for the use of this method for strengthening pharmacological activity of antitumor drugs, including in combination with nanoparticles. Product Description popup.authors Kolesnik Denis L. Pyaskovska Olga M. popup.nrat_date 2021-01-02 Close