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Information × Registration Number 0221U000143, 0117U000096 , R & D reports Title Synthesis of heterocyclic nitrogen and organo-phosphorus compounds and research of their biological activity. popup.stage_title Head Vovk Andrii I., д.х.н. Registration Date 02-01-2021 Organization V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine popup.description2  An effective method for the synthesis of hydroxylated homoisoflavonoids has been developed, which does not require protection of phenolic groups. Preparative methods for the synthesis of pyrido[2,3-d]pyrimidin-7-one derivatives containing residues of primary and secondary amines at position 4 of the heterocyclic system have been developed. Asymmetric synthesis of (RS)- and (RR)-S-alkyl-substituted cysteine sulfoxides was performed. The properties of new rhodanine derivatives as inhibitors of glutathione-S-transferase and protein tyrosine phosphatases have been established, and the antioxidant activity of potentially bioactive phosphorylated coumarins has been evaluated. The antitumor effect and the results of computer simulation of the activity of acylated 6-aminopurines and their structural analogues aimed at BRD4, xanthine oxidase, cytosolic 5'-nucleotidase II and CD-kinase were compared. The role of stable radicals TEMPO and TEMPOL in the regulation of electron transport in the respiratory chain of the model plant A. thaliana in the formation of a protective response of the cell in response to exogenous purified inducers of resistance - flg22 or attack of flagellin-containing pathogens Pseudomonas syringa were detected. Product Description popup.authors Іvanova Іryna V. Abdurakhmanova Esma R. Biletska Іryna M. Biletskii Igor І. Brovarets Volodymyr S. Buldenko Vladyslav M. Bukhonska Yaroslava К. Veligina Yevheniia S. Verves Evgeniy V. Verevka Oleg S. Vydzhak Roman M. Gaevsky Anatoly Р. Herasymov Yehor S. Golovchenko Оlexander V. Grishkun Evgeny V. Hushcha Tatiana О. Didiv Nataliya D. Demydchuk Bogdan A. Derevyanchuk Michael V. Zhirnov Viktor V. Zinchenko Hanna M. Zyabrev Volodymyr S. Kibirev Volodymir K. Kachaeva Maryna V. Kachkovskyi Oleksiy D. Klyuchko Svitlana S. Kobzar Oleksandr L. Kozachenko Olexandr P. Kolesnikov Yaroslav S. Kolodiazhna Anastasiya O. Kolodiazhna Olga O. Kolodiazhnyi Oleg I. Kondratyuk Kostyantyn M. Kravets Volodymyr S. Kretynin Serhiy V. Kukuyev Maksym О. Kucher Oleksandr V. Mityukhin Оleg P. Mischenko Iryna M. Melnyk Andrii К. Merzhievskiy Danylo O. Mykula Mariya S. Moskvina Viktoria S. Mrug Galyna P. Muzychka Lyubov V. Muzychka Oxana V. Nikolayevska Valentyna І. Osadchuk Tetiana V. Ocheretnyuk Alla D. Pilyo Stepan G. Panchyshyn Svitlana Ya. Plokhovska Svitlana H. Pokotylo Igor V. Polovko Тetiana A. Porhun Svitlana V. Prisyajnyuk Dmitry V. Prokopenko Volodumir M. Prostota Yaroslav A. Rentsevych Тetiana L. Synenko Vitaliy O. Slastennikova Alyona O. Slyvchuk Serhiy R. Smolii Oleg B. Solomiannyi Roman M. Sukhoveev Olexandr V. Tanchuk Vsevolod Yu. Tatarchuk Alʹona V. Frasinyuk Mykhaylo S. Charochkina Larysa L. Chumachenko Svitlana A. Shablykin Оleg V. Shablykina Olga V. Shejko Sergij Y. Shulga Yrij V. Yakovenko Oksana М. Yaremchuk Iryna О. popup.nrat_date 2021-01-02 Close