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Information × Registration Number 0221U000215, 0120U105437 , R & D reports Title Molecular design, creation, in vitro and in vivo screening of nanocomplexes of natural alkaloids with C60 fullerene to increase the effectiveness of metastatic cancer therapy. popup.stage_title Head Prylutskyy Yuriy I., Доктор фізико-математичних наук Registration Date 03-01-2021 Organization Taras Shevchenko National University of Kyiv popup.description2 The object of research is the interaction of C60 fullerene with BDB molecules. The purpose of the work is to determine the antitumor activity of the C60-BBR nanocomplex. Research methods - dynamic light scattering, high performance liquid chromatography, molecular dynamics, docking. Using the original ultrasonic technology and spectroscopic method, a water-soluble nanocomplex C60-BBR in different molar ratios of the components was prepared and characterized. Using molecular dynamics, the C60 fullerene nanocomplex with 5 non-covalently bound BBR molecules has been shown to be the most stable in the aqueous medium. Using high performance liquid chromatography, it was found that C60-BBR nanocomplexes release BBR molecules faster in an acidic (tumor site modeling) than in a physiological environment. The results of molecular docking show that the C60 molecule, loaded with BDB, reliably binds to the P-gp plasma membrane transporter protein due to Van der Waals forces and induces its conformational changes.  Product Description popup.authors Gurmach Vasyl V. Prylutsʹka Svitlana V. Franskevych Daria V. popup.nrat_date 2021-01-03 Close