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Information × Registration Number 0221U100256, 0115U003748 , R & D reports Title Expression of genes encoding enzymes of folate-related metabolism and trassulfuration and gene expression profiles in human placenta at three trimesters of gestation popup.stage_title Head Obolenska Mariia Yu., Registration Date 04-01-2021 Organization Institute of Molecular Biology and Genetics of NAS of Ukraine popup.description2 Results. The reduction of mRNA abundance encoding folate-dependent metabolism enzymes in the third trimester of pregnancy compared to the first. The appearance of the monofunctional enzyme GARS in the first trimester along with the canonical trifunctional enzyme GART; reduction of newly formed purines and increase of S-adenosylmethionine and S-adenosigomocysteine under the influence of homocysteine, which leads to a shift of metabolic flows towards the methionine cycle at expense of folate-dependent processes and de novo purine synthesis, particularly. We created a specific database of gene expression in the human placenta and placental structures during physiological and pathological course of gestation. The data in normal placenta were integrated and a list of genes whose expression differs between the first and the second and the second and the third trimesters was determined. The algorithm for analyzing gene expression data will be implemented in a cloud environment where they will be available for the free use by scientists of NASU.   Product Description popup.authors Likhenko Oleksand K. Martseniuk Olha P. Frolova Alina O. popup.nrat_date 2021-01-04 Close