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Information × Registration Number 0221U100271, 0118U003768 , R & D reports Title To study the dependence of the processes of proliferation and differentiation of progenitor cells in the bone marrow on the functional state osteon in children with acute leukemia, osteoporosis and collagenopathy in the remote period after the Chernobyl accident popup.stage_title Head Bruslova Kateryna M., Registration Date 04-01-2021 Organization State Institution "National Research Centre For Radiation Medicine of National Academy of Medical Sciences of Ukraine" popup.description2 The object of the study - 754 children: 134 patients with acute leukemia, 263 with connective tissue dysplasia, 357 comparison groups.The aim is to increase the effectiveness of treatment of patients with acute leukemia in the long term after the Chernobyl accident by studying the dependence of proliferation and differentiation of bone marrow progenitor cells from the functional state of osteon and improve measures to correct disorders in children with collagenopathies and osteoporosis. Methods - cytological, biochemical, biophysical, immunological, statistical. List of equipment - light microscope, hemoanalyzer, biochemical and amino acid analyzers, densitometer. For the first time, the effectiveness of treatment measures in children with acute leukemia increased depending on the processes of differentiation of bone marrow cells, osteon and hormones, that regulate osteogenesis, which contributed to a positive effect in 65,6%, partial -in 24,4% of patients.Correction of disorders in children with connective tissue dysplasia, which are a risk group for oncohematological pathology, showed a positive effect in 73,6%, partial -in 19,4%. The prognosis of acute leukemia in children depended on the state of osteon, starting with the activity of stromal fibroblasts.Decreas number of colony-forming units of bone marrow fibroblasts, low levels of osteocalcin and calcium in serum, deficiency of glycine in urine, increased activity of alkaline phosphatase in blood serum, as well as low densitometry children, showed changes in osteon and bone marrow stroma and adversely affected the survival of children.The share of deaths in children with changes in the state of osteon was 43,8% versus 8,2% in patients without changes in the processes of osteoformation.The radiation dose in patients with acute leukemia was (5,37±1,23) mSv, in children with connective tissue dysplasia - (0,46±0,07)mSv, in the comparison group - (0,46±0,06)mSv and these doses were not related to other indicators. Product Description popup.authors Ilyenko Iryna M Bazyka Dymytriy A Bruslova Kateryna M Vasylenko Valentyna V Volodina Tetyana T Gonchar Larysa O Kavardakova Nataliya V Lyashenko Lyudmyla O Pushkareva Tetyana I Trykhlib Iryna V Tsvetkova Nataliya M popup.nrat_date 2021-01-04 Close