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Information × Registration Number 0221U100374, 0118U003771 , R & D reports Title The analysis of neuroendocrinological effects of prenatal exposure by incorporated 131І popup.stage_title Head Kaminskiy Oleksyi V., Доктор медичних наукLohanovskyi Kostiantyn M., Talko Victoria V., Доктор медичних наук Registration Date 05-01-2021 Organization State Institution "National Research Centre For Radiation Medicine of National Academy of Medical Sciences of Ukraine" popup.description2  The object of the study was the neuroendocrine effects in Wistar rats irradiated in utero 131I. The state of cognitive functioning, emotional-behavioral sphere and endocrine system in 101 irradiated in utero due to the Chernobyl accident and 54 unexposed persons in utero. Objective - To determine in the experiment morphofunctional changes in the structures of the brain and organs of the endocrine system in prenatally irradiated 131I rats. To establish the role of disorders of the endocrine system in the pathogenesis of neuropsychiatric effects of prenatal irradiation of the brain due to the receipt of 131I at different stages of gestation. Research methods - behavioral, enzyme-linked immunosorbent assay, biochemical, morphological, cultivation of primary cultures of thyroid tissue cells; clinical neuropsychiatric, neuro- and psychometric, neuropsychological, neurophysiological, endocrinological, statistical, dosimetric. It was found that in irradiated in utero rats the most pronounced negative changes in conditioned reflex instrumental activity, neuroimmune, morphofunctional disorders in brain structures and in the primary culture of thyroid cells (binuclear cells, micronuclei, apoptosis, differentiation disorders) occur due to the receipt of 131I at the stage of the final structural and functional formation of the fetal thyroid gland (14th day of gestation). In irradiated in utero individuals found a higher incidence of non-malignant thyroid pathology (60% vs. 50% in the control group), mostly nodular non-toxic goiter (28% of subjects), a significant prevalence of hyperplasia of the thyroid gland(32% vs. 17% in the control group). A probable diffuse decrease in the absolute and relative spectral power of the theta range of the kEEG, which is considered a marker of hippocampal function, in proportion to the increase in radiation dose in utero. Product Description popup.authors Antypchuk Kateryna Yu Atamaniuk Natalia P Afanasiev Dmytro Ye Gresko Maryna V Dmytriyeva Inna R Kreynis Georgiy Yu Kuts Kostiantyn V Lavrenchuk Galyna Yo Loganovskaya Tatiana K Malyshevska Yevgheniya M. Masuk Sergiy V Perchuk Iryna V Pleskatch Oksana Ya Chernyshov Andriy V popup.nrat_date 2021-01-05 Close