Search academic texts

Information × Registration Number 0221U100455, 0119U102333 , R & D reports Title Magnetite-doped biogenic hydroxyapatite as a carrier of antibacterial drugs for medical using popup.stage_title Head Otychenko Oksana M., Registration Date 05-01-2021 Organization Institute for Problems in Materials Science popup.description2  Materials Ca10(PO4)6(OH)2 / FeC2O4 were obtained by mechanical mixing of Ca10(PO4)6(OH)2 and FeC2O4 in the form of hydrosuspension (mechanical method) and through the introducing BHA directly in the process of obtaining an iron oxalate precipitate (chemical method). In order to obtain the Ca10(PO4)6(OH)2 / Fe3O4 composite systems, the synthesized materials Ca10(PO4)6(OH)2 / FeC2O4 are subjected to heat treatment in protective and restorative media for 2 h at T = 500 ºС. It was found that the addition of FeO·Fe2O3 (nominally magnetite) leads to an increasing in the rate of solubility of biomaterials BGA / FeO·Fe2O3 and more uniform nature of its decreasing within 7 days. It is determined that the adsorption processes in the interaction of BGA with amoxyl-K and cefotrin occur mainly due to additional surface modification by protective substances of the antibiotic (clavulanic acid and L-arginine). The chemically synthesized BGA / FeO·Fe2O3 composite system was found to have the lowest adsorption activity to ceftriaxone. However, the reason for this is probably the more intensive formation of sparingly soluble compounds of the antibiotic with Fe (III) ions, where ceftriaxone reduces the toxicity of iron, while maintaining its immediate properties. Product Description popup.authors popup.nrat_date 2021-01-05 Close