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Total number
Full text
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0221U100533,
0120U104982
,
Neuroprotective action of vitamin D3 in glucocorticoid-induced neurotoxicity
Isaiev Dmytro S., Доктор біологічних наук
07-01-2021
Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine
Natural glucocorticoids (NG) and their synthetic analogues are widely used in medical practice due to their anti-inflammatory, desensitizing, immunosuppressive, anti-allergic and anti-shock properties. However, long-term use of NG increases the risk of developing a number of complications, including their significant toxic effects on the central nervous system. The implementation of the main tasks of the Project is aimed at clarifying the mechanisms of development of structural and functional disorders in the CNS and cognitive-behavioral disorders under the action of NG, as well as finding ways for their pharmacological correction is an urgent medical and biological problem. At this stage, a method of histological analysis of brain regions has been developed for further studies of the neurotoxicity of NG and the protective effect of vitamin D3.
Isaiev Dmytro S.
2021-03-17
Updated: 2025-12-07
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