Search academic texts

Information × Registration Number 0221U100700, 0119U101624 , R & D reports Title Synthesis, spectral-luminescent properties of new alkylamino-beta-ketoenol compounds and metal complexes based on them to produce fluorescent probes of biomolecules and optical materials popup.stage_title Head Pekhno Vasyl I., Доктор хімічних наук Registration Date 08-01-2021 Organization V.I. Vernadskii Institute of General & Inorganic Chemistry NAS of Ukraine popup.description2  The alkylamino-β-ketoenol dye 2-(E, 5Z, 7E)-8-(4-(dimethylamino)phenyl)-6-hydroxy-2-(2-methoxyethyl-amino)octa-25,7-trien-4-one (AmyGreen) were synthesized and investigated. The AmyGreen dye has been proposed as an effective fluorescent probe capable of visualizing bacterial amyloids in biofilms as well as detecting pathological amyloids in vitro. In solution, AmyGreen increases its fluorescence intensity tenfold in the presence of amyloid fibrils and gives a low fluorescence reaction in the presence of various biomolecules. AmyGreen provides fluorescent staining of amyloids in bacterial biofilms, which allows you to visualize the amyloid components of the biofilm with higher resolution. Product Description popup.authors Ilnytska Olena L. Dovbii Yan M. Kovalska Vladyslava B. Losytsky Mykhailo Yu. Moshynets Olena V. Selin Roman O. Tretyakova Irena M. Chernii Viktor Ya. popup.nrat_date 2021-03-17 Close