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Information × Registration Number 0221U100713, 0119U101473 , R & D reports Title Study of hormonal and metabolic pathways of parathyroid disorders in survivors exposed to ionizing radiation as a result of the Chornobyl accident popup.stage_title Head Kaminskyi Oleksii V., Доктор медичних наук Registration Date 08-01-2021 Organization State Institution "National Research Centre For Radiation Medicine of National Academy of Medical Sciences of Ukraine" popup.description2  Research report: 107 pages, 19 tables, 35 figures, 134 sources, 4 appendices. Chornobyl NPP accident, ionizing radiation, parathyroid glands, thyroid gland, hormones. Object of research: clinical effects of ionizing radiation on the endocrine system in 164 subjects affected by the Chornobyl NPP accident and 90 their descendants, compared with the general population; assessment of data from 6,000 persons to detect the parathyroid hyperplasia and develop a methodology for ultrasound examination. Objective: to determine the hormonal and metabolic status of the endocrine system on the basis of a clinical examination in persons affected by the Chornobyl NPP accident and their descendants having got parathyroid disorders. Research methods: generally accepted clinical, anthropometric (body weight, height, thigh volume, body mass index assay), instrumental (thyroid and parathyroid ultrasound examination), laboratory (biochemical, hormonal), statistical. It was determined that the Chornobyl NPP accident clean-up workers (ACUW), 30-km exclusion zone evacuees, residents of contaminated areas, and the control group subjects in which parathyroid hyperplasia was detected have no significant difference in the incidence of carbohydrate metabolic disorders. There was a significant increase in the incidence of hypertension among the ACUW who had parathyroid hyperplasia (76.9 %) vs. the control group (51.2 %). Vitamin D levels were significantly lower in subjects with parathyroid hyperplasia than without it. Vitamin D lack/deficiency was found in 94 % of the surveyed persons. It was determined that the average serum level of parathyroid hormone was significantly higher (57.2±2.87 pg/ml) in the Chernobyl NPP ACUW of the iodine period, in which PSH hyperplasia was detected, than in the control group (p < 0.05). Multifactorial analysis showed a strong association of vitamin 25(OH)D lack/deficiency with the development of thyroid disorders, carbohydrate metabolic disorders, cardiovascula Product Description popup.authors Afanasyev Dmytro E. Kaminskiy Oleksiy V Копилова Ольга Василівна Muraviova Iryna M. Tepla Olena V. Chykalova Iгyna G. popup.nrat_date 2021-03-17 Close