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Information × Registration Number 0221U101021, 0120U104882 , R & D reports Title Creation of new effective inhibitors of Zring formation in order to obtain anti-tuberculosis drugs with antimitotic action popup.stage_title Head Karpov Pavlo A., к.б.н. Registration Date 12-01-2021 Organization Institute of Food Biotechnology and Genomics of the National Academy of Sciences of Ukraine popup.description2  Based on the structural-biological study of priority molecular targets of the mitotic apparatus Mycobacterium and its effectors, libraries of potential target and focal inhibitors (23,734 biologically active substances) were developed. According to the results of molecular docking and molecular mechanics, 68 compounds with the best energy binding parameters to FtsZ M.tuberculosis and M. bovis were selected, from which 7 leaders differing in heterocyclic skeleton scaffold were selected for further biochemical study in vitro. Primers were selected and a polymerase chain reaction protocol was developed to identify Mycobacterium spp. The threshold sensitivity of the M. bovis vaccine strain to rifampicin and streptomycin has been established, which is necessary for further testing of biologically active compounds. A protocol for determining the antimicrobial action of cell division inhibitors using the vaccine strain M. bovis has been developed. Product Description popup.authors Ishchenko Liudmila M. Borusov Olexandr V. Vyhovska Liliia M. Karpov Pavlo A. Labudzynskyi Dmytro O Мазур Valeriy M. Ozheredov Sergey P. Raievskyi Oleksii V Samofalova Dariya O. Svistunov Sergey Ya Spivak Svitlana I. popup.nrat_date 2021-01-12 Close