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Information × Registration Number 0221U101244, 0118U003043 , R & D reports Title To study early biological predictors of development of neurodegenerative pathology and to work out approaches to prevent impairments of brain functions (an experimental research) popup.stage_title Head Berchenko Olga G., Доктор біологічних наук Registration Date 18-01-2021 Organization State institution "Institute of Neurology, Psychiatry and Narcology, National Academy of Medical Sciences of Ukraine" popup.description2  ALZHEIMER’S DISEASE MODEL, PARKINSON’S DISEASE MODEL, COGNITIVE PROCESSES, OLFACTORY SENSORY SYSTEM, SLEEP, MIR-101, β-AMYLOID PEPTIDE, DOPAMINE, CYTOKINES. Object of research was 125 laboratory rats; 6 samples of human blood mono-nuclear cells. The aim of the study was to study early neurobiological disorders of brain function in experimental amyloidogenic and nigrostriatal pathologies and to deter-mine the corrective effect of miR-101 in liposomal form (in Alzheimer's disease) and low doses of dopamine (in Parkinson's disease) under conditions of their intranasal administration. Research methods were neuroethological, neurophysiological, enzyme-linked immunosorbent assay, polymerase chain reaction, fluorescent, mathematical-statistical. List of measuring equipment is Annex A. In experimental models revealed a continuum of early systemic disorders of spatial and working memory, central mechanisms of olfactory information pro-cessing, sleep, neuroinflammatory processes in the accumulation of toxic β-amyloid peptide Aβ42 in the hippocampus of rat brain with simulation of Alzheimer's dis-ease and a decrease in dopamine in the caudate nucleus in experimental Parkinson's disease. New approaches to the correction of brain disorders by influencing the specific mechanisms of neurodegenerative pathology have been developed: reduc-tion of the formation of excess β-amyloid peptide under the condition of blocking the translation of its precursor by liposomal miR-101 in experimental Alzheimer's disease; replenishment of dopamine in the striatum under conditions of intranasal administration of small doses of dopamine in experimental Parkinson's disease. Product Description popup.authors Bevzyuk Dar'ya O Geyko Valentyna V Kirichenko Olga V Levicheva Natalia O Pivnenko Iryna V Sokolik Victoriy V Titkova Anna Anna M. popup.nrat_date 2021-01-18 Close