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Registration Number

0221U101264, 0117U006276 , R & D reports

Title

Development of new generation implants is based on synthetic bone tissue analogues and mesenchymal stem cells for bone tissue damage reconstruction.

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Head

Piven Oksana O., Кандидат біологічних наук

Registration Date

18-01-2021

Organization

Institute of Molecular Biology and Genetics of NAS of Ukraine

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 During the implementation of the project phase, a computer model of bone tissue damage in small rodents was obtained using software tools in the Solidwork environment. Due to this, the optimal location, the size of the penetrating perforated injury and the force during the injury were determined and characterized. The obtained parameters were used in the simulation of bone operable trauma in model animals - Wistar rats. As a result, we developed a model of shin bone damage and analyzed the dynamics of its regeneration under control conditions with the help of radiography. In general, it is shown that perforated trauma should be applied with a size of less than 10 mm, topographically between the zones of margo medialis and tibia with a mechanical load of 1.9 N / m2. The perforated trauma formed according to such parameters is characterized by positive dynamics of healing, on the 18th day the formation of callus in experimental animals is observed, complete tissue recovery occurred after 20 days of observations.

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Macewicz Larysa L
Papuga Olexander Ye.
Ruban Tetiana P

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2021-01-18