Search academic texts

Information × Registration Number 0221U101283, 0120U104127 , R & D reports Title Neuroprotective action of vitamin D3 in glucocorticoid-induced neurotoxicity popup.stage_title Head Shimanskiy Igor O., Кандидат біологічних наук Registration Date 18-01-2021 Organization Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine popup.description2 Evaluation of vitamin D bioavailability in experimental animals with chronic administration of the synthetic glucocorticoid drug prednisolone revealed a significant decrease in the content of 25OHD in the serum. There was also a positive correlation with a decrease in the content of 25OHD in the central nervous system. Significant, presumably compensatory, increase in the expression of VDBP, CYP27B1, CYP24A1 and VDR in brain tissue with chronic prednisolone has been shown. These changes were accompanied by impaired cytoarchitectonics in various structural parts of the brain. There was a decrease in K+ -depolarization-induced exocytosis in isolated nerve terminals, as well as inhibition of Ca2+-dependent fusion of vesicles with synaptic membranes under the neurotoxic effect of prednisolone. Therapeutic administration of vitamin D3 partially corrected long-term prednisolone-induced brain damage in rats. Product Description popup.authors Isaiev Dmytro S Veliky Mykola M Lisakovska Olha O. Labudzynskyi Dmytro O Khomenko Anna V popup.nrat_date 2021-01-18 Close