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Information × Registration Number 0221U101514, 0118U003581 , R & D reports Title Physical basis for the formation of apatite-biopolymer porous matrices for controlled delivery of drugs to the implantation zone popup.stage_title Head Sukhodub Leonid F, Доктор фізико-математичних наук Registration Date 22-01-2021 Organization Sumy State University popup.description2 The object of research: processes of formation of hybrid biomaterials with the incorporation of medical bioactive substances, in vitro kinetics of drug release into the model biological environment; physical properties, structure, composition and bioactivity of apatite-polymer samples; mechanical properties of composites; biocompatibility and cytotoxicity of biomaterials containing ions and nanoparticles of transition metal oxides. The purpose of the work - synthesis and structural-spectral studies of the latest biopolymer-apatite materials for bone remodelling and providing the controlled release of drugs; development of methods for obtaining functional nanostructured materials in various physical forms (powders, hydrogels, films, granules, scaffolds). The following is done: developed the technological bases of synthesis and created laboratory samples of alginate (Alg) -hydroxylapatite (HA) composites in the form of thin films (up to 2mm ) with the content of Cu2 +, Zn2 + ions; proven their antimicrobial activity; created laboratory samples of bioactive granulated (dr = 2mm) composites based on HA with immobilized 0.05 and 0.5 wt.% multiwall (MWCNTs) and single-walled (SWCNTs) carbon nanotubes; synthesized composite biomaterial based on HA, Alg and graphene oxide (GO) and established structural-phase and mechanical dependences on the GO content; obtained single-phase coatings of HA (300 μm) and Bruschite (50 μm) on Ti6Al4V substrates treated with plasma electrolytic oxidation using the method of thermodeposition; created polyelectrolyte composite based on HA, Alg and chitosan (CS) with C60 fullerene content. Product Description popup.authors Inshina Nataliya M Honcharova Svitlana A. Diadiura Kostiantyn O. Kumeda Mariia O Prylutskyy Yuriy I Sukhodub Lyudmyla B popup.nrat_date 2021-01-22 Close