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Information × Registration Number 0221U101527, 0117U001729 , R & D reports Title Experimental estimation of the effectiveness of application and biocompatibility testing algorithm of domestic implantation materials, based on calcium phosphates, for the restoration of the function of the musculoskeletal system in the malignant process. popup.stage_title Head Lukianova Nataliia Yu., Доктор біологічних наук Registration Date 22-01-2021 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine popup.description2  The ratio of molecular-biological parameters associated with the tumor process on the level of organism in Wistar rats with Walker-256 carcinosarcoma was analyzed after implantation of domestic implant materials based on calcium phosphates. It was found that in the blood of animals with implanted in the tibia biomin, there is an increase in circulating miRNA-155 and -125b in 1.8 (p <0.05) and 1.6 (p <0.05) times, respectively, and the increase in the level of C -reactive protein 1.4 times (p <0,05). In addition, in the blood of studied animals with Walker-256 carcinosarcoma we observed an increase in the number of erythrocytes and platelets on the background of a decrease in hemoglobin. Studies of bone regeneration at the site of biomine implantation using electron microscopy revealed active, synchronous processes of resorption of implants with their replacement by collagen masses with subsequent mineralization, as well as proliferation of osteoblasts and osteoclasts. In the analysis of cytomorphological features of vital organs of animals with Walker-256 carcinosarcoma after biomine implantation, minor dystrophic changes were found only in hepatocytes and epitheliocytes of the proximal tubules of the kidneys, which may be due to increased bile synthesis and detoxification in the liver. tumor secretion of specific proteins. Thus, the results of studies of the processes of regeneration of the tibia of animals with Walker-256 carcinosarcoma indicate the presence of osteoinductive and osteintegrative effect of biomine at the site of implantation. Changes in blood parameters and cytomorphological features of vital organs of animals with Walker-256 carcinosarcoma, which implanted biomin in the tibia , are probably the result of disorders of epigenetic regulation of proteins, and indicate the absence of its toxic effects. Product Description popup.authors Borikun Tetiana V. Zadvornyi Taras V. Chekhun Vasyl F. popup.nrat_date 2021-01-22 Close