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Information × Registration Number 0221U101557, 0116U001411 , R & D reports Title To study the physiological and biochemical mechanisms of toxic effects of organophosphorus compounds on organism of animals popup.stage_title Head Salyha Yuriy T, Доктор біологічних наук Registration Date 22-01-2021 Organization Institute of Animal Biology of NAAS popup.description2 Laboratory rats and Zebrafish (Danio rerio) as an excellent biological model were used for research of pro-antioxidant balance, hematological and behavioral parameters of organism of Chlorpyrifos (CPF) poisoning. Theoretically oxidative stress as one of the main mechanisms of bio toxicity of organophosphates was confirmed. It was been shown that CPF disorders the neurobehavioral parameters of females and their offspring in rat poisoning with low doses of this compound prior to fertilization. It was found that the low doses of CPF did not cause significant neurobehavioral abnormalities in female rats, but provoke the symptoms similar to the manifestations of attention deficit hyperactivity disorder (ADHD) in their offspring. An improved and supplemented complex scheme of physiological and biochemical mechanism of CPF toxicity, which does not limit to the well-known anticholinesterase effect, but is also closely interrelated with the phenomenon of oxidative stress was proposed. The peculiarities of free radical processes have been found and also the methodological approach to evaluate the consequences of chronic and acute CPF poisoning in adult animals and their offspring has been developed. Zebrafish as biological model have been used in investigeting the physiological and biochemical parameters of the toxic effect of chlorpyrifos. For the first time in Ukraine, the method to measure the neurotoxicity and other effects of xenobiotic on a living organism with the using Danio rerio aquarium fish as model was developed Product Description popup.authors Dzen' Yevhen O Dovhaniuk Vasyl V Korbetska Olga O Rosalovsky Volodymyr P Saviak Zoriana I. popup.nrat_date 2021-01-22 Close