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Information × Registration Number 0221U101618, 0116U002935 , R & D reports Title Risk factors of the progress of essential hypertension and metabolic syndrome at the comprehensive assessment of hemodynamic, kidney function, circadian structure of blood pressure in the substantiation of antihypertensive therapy popup.stage_title Head Плеш Ihor A, Registration Date 23-01-2021 Organization HSEE of Ukraine "Bukovinian State Medical University" popup.description2  The heterogeneity of the pathogenetic structure of patients with II and III st. of EH according to the options of the circadian rhythm of blood pressure was proved for the first time. For the first time it was found that in patients with consistently high blood pressure during the day (ND) and exceeding zero blood pressure over day (NP) in a large part of EH is combined with elevated and high central venous pressure (CVP), which is caused by reduced efficiency of physiological renal mechanism “blood pressure - sodium". It has been confirmed for the first time that the main mechanism of CVP growth is slowing of venous blood flow, BCC growth, progressive decrease in renal activity to regulate VCB compliance with vascular volume. For the first time, some aspects of the effect of thiazide diuretics have been supplemented. For the first time, a clinical test to control the diuretic dose adjustment was substantiated. For the first time, the possibility of using thiazide diuretics in combination with thiazide-like diuretics at different doses and mechanisms of action was expressed. Product Description popup.authors Boreyko Lilya D Gaidych Lesya I. Kshanovska Anna I. Mararash Halyna H Slyvka Nataliia O popup.nrat_date 2021-01-22 Close