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Registration Number

0221U101659, 0117U007737 , R & D reports

Title

To study pathogenetic mechanisms of occurrence of deformations of lower extremities in patients with rheumatoid arthritis, to develop new and to improve existing methods of their prevention and treatment

Head

Herasymenko Serhii І., Доктор медичних наук

Registration Date

23-01-2021

Organization

SI “The Institute of Traumatology and Orthopedics by NAMS of Ukraine"

Description

 The object of the study - clinical, radiological, cultural and biomechanical parameters of 289 patients with late stages of rheumatoid arthritis with lesions of the hip and knee joints. The aim of the work is to improve the results of treatment of patients with rheumatoid arthritis on the basis of developing a comprehensive approach to total hip and knee arthroplasty with different options for their simultaneous defeat. Research methods - clinical, radiological, biomechanical, histological, cultural, microscopic, immunological, statistical; full-scale experiment. Research results. The analysis of the influence of the activity and duration of rheumatoid arthritis (RA), taking anti-inflammatory drugs on the increase of movements in the knee joint after its endoprosthesis. The relationship between activity, duration of pathological process, therapy and morphocortical index, and patient status on the Harris scale after hip arthroplasty, on the scale of Joseph J., Kaufman E. E. in the postoperative period of 6 months. up to 1 year after knee replacement surgery. The computer model was used to study changes in biomechanics in the hip and knee joints, the load of the components of the knee joint endoprosthesis during the correction of axial deformities. In a field experiment, changes in the pressure in the hip and knee joints when changing the position of the bones that articulate them were studied. Using histomorphometry, the condition of the bone tissue of the articular ends of the knee joint in patients with RA at later stages was studied. Osteogenic activity, immunological and microbiological changes in this category of patients were studied.

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Babko Andriy M
Batanova Nina Yu.
Haiko Oksana H.
Gerasymenko Andrey S
Grigorovsky Valerii V.
Gromadsky Viacheslav M
Guzhevs'kyj Igor V
Duda Maksym S
Kostogryz Yurii O
Lazarev Ihor A
Lenec Olga V
Lyutko Olga B
Mandryk Petro T
Nemyrovych-Bulgacova Oksana I.
Nechiporenko Roman V.
Panchenko Lesya M
Perfilova Lidiya V
Polovynka Lidia O
Polulyakh Dmytro M
Poluliakh Mykhailo V
Pshenychnyy Taras E
Sydorec Galyna I.
Sokolovska Olga R
Tymochuk Victor V
Shapoval Ludmyla I.
Shevchenko Аnna M