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Information × Registration Number 0221U101786, 0118U003209 , R & D reports Title To develop new technologies of metabolic therapy based on epigenetic characteristics of tumors in patients with cancer of the gastrointestinal tract popup.stage_title Head Krasnoselskiy Mikola V., Доктор медичних наук Registration Date 25-01-2021 Organization State Organization "Grigoriev Institute for Medical Radiologiy of the National Academy of Medical Sciences of Ukraine" popup.description2 Research object: combined treatment of gastrointestinal tract (GIT) cancer, metabolic disorders, epigenetic characteristics. Purpose of the work: to increase the efficiency of treatment of patients with gastrointestinal tract cancer by individualizing metabolic therapy at the stages of combined treatment taking into account epigenetic disorders. Research methods and equipment: clinical and instrumental, biochemical, statistical, chromatographic, polymerase chain reaction method, biochemical analyzer ResponsT910, hematological analyzer automatic XN-L550. Theoretical and practical results: for the first time, four patterns have been identified that characterize the ratio of carbohydrate, lipid and protein metabolism after radical removal of a malignant tumor. It was shown that methylation of the PTEN gene leads to deeper disturbances in metabolic processes towards gluconeogenesis. Clarification of the direction of metabolic correction for the treatment of energy deficiency and catabolic processes allows individualizing metabolic therapy at the stages of combined treatment. Two methods have been developed for the surgical treatment of pelvic cancer. Novelty: for the first time, the influence of epigenetic features on metabolic disorders in patients with gastrointestinal cancer was determined. The scientific data on metabolic disorders in patients with gastrointestinal tract cancer at different stages of combined treatment have been clarified. The program of individual metabolic therapy has been substantiated. Efficiency of application: increasing the efficiency of treatment of patients with gastrointestinal cancer by individualizing metabolic therapy at the stages of combined treatment, taking into account epigenetic characteristics. The field of application: oncology.  Product Description popup.authors Verbytskyi Maksym V. Holubieva Larysa V. Hranovska Hanna I. Krutko Yevhen M Kulshyn Volodymyr Ye. Lanko Liliia H. Movchan Oleksii V. Molodan Liudmyla Volodymyrivna Muzhychuk Ivan V. Nemaltsova Kateryna V. Pidlisnyi Ruslan A. Pavlichenko Yuliana V. Perepadia Oksana V. Popovska Tetiana M. Radchenko Oleksandr A. Revenkova Svitlana I Svynarenko Andrii V. Slobodianiuk Olha V. Khramtsov Roman Ye. Cherkasko Liudmyla V. popup.nrat_date 2021-01-25 Close