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Information × Registration Number 0221U102134, 0116U008928 , R & D reports Title Epigenetic mechanisms of physical factors action upon brain structures and homeostasis popup.stage_title Head Hodlevskyi Leonid S, Registration Date 28-01-2021 Organization Odessa National Medical University popup.description2  The object of the study was 239 sexually mature white Wistar rats. The purpose of the work was to determine the pathogenetic mechanisms of epileptic syndrome during Transcranial direct current stimulation (TDCS) of the cerebellum and cerebral cortex and to study the conditions for achieving a pronounced anticonvulsant action. It was found that the TDCS of the cerebellum, regardless of the polarity of the electrode, causes anticonvulsant effects in the model of pentylenetetrazole (PTZ) -induced kindling. On the model of maximum electroshock seizures, differences in the dynamics of the development of anticonvulsant effects were established under conditions of using the cathode and anode. The role of the old cerebellar cortex (lobule VI) in the implementation of anticonvulsant effects and their potentiation with axitinib, a tyrosine kinase B blocker, was determined. The proepileptogenic effect of silver nanoparticles was revealed. The role of peroxisomal proliferator-activated receptors (PPARγ) in the development of antiepileptic effects has been shown. Product Description popup.authors Bidnyuk Katerina A Godlevsky Leonid S Mandel Olexandr V Nenova Oxana M Pervak Michaylo P Ponomarenko Andrii I Poshivak Olesya B Prybolovets Tetyana V Son Ganna O Tatarchuk Tetyana V popup.nrat_date 2021-01-28 Close