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Information × Registration Number 0221U102272, 0120U102323 , R & D reports Title Functionally Oriented Nanoscale Heterostructures Based on Antiviral, Antitumor, and Antibacterial Transition Metal Compounds popup.stage_title Head Pekhno Vasyl I., Доктор хімічних наук Registration Date 29-01-2021 Organization V.I. Vernadskii Institute of General & Inorganic Chemistry NAS of Ukraine popup.description2 Five π-complexes with 1-allyl-3- (2-hydroxyethyl) thiourea have been obtained, which can be considered as potential biologically active substances that can overcome the resistance of cancer cells due to the realization in their structure of the effect of "molecular antisymbiosis in trans- influence of "Pearson. The study of compounds by X-ray diffraction showed that all complexes are isostructural. Agarose gel electrophoresis studies have shown that all test compounds exhibit nuclease-like activity and are able to form single- and double-stranded plasmid breaks by direct DNA cleavage. The identified in vitro DNA binding activity of the new π-complexes indicates the viability of their further in vitro studies to identify their potential antiproliferative activity. The crystal structure of PyrHMDP was synthesized and determined, the protonation constants of PyrHMDP and the formation constants of Pd (II) complexes with PyrHMDP were calculated. The processes of complexation in the system Agedta, Agedds, Auedta, Auedds are investigated. The method of coordination of t.i. with functional groups of the ligand. Nanodisperse systems based on synthesized compounds are obtained. The particle size depends on the Central ion of the complexing agent. All the resulting systems are aggregatively stable. Complexes and systems are characterized by physicochemical methods of 1H NMR, IR, ESP and SDV, DRS, SEM. A method for the synthesis of hybrid systems by covalent fixation of argentum and aurum curcuminates on a highly dispersed surface of kaolin and halogenite has been developed. It is shown that the maximum fixing efficiency with the formation of uniform structures can be achieved by heterophase synthesis. All test powders were found to inhibit the growth of bacteria. Gold nanosystems proved to be more active than silver systems against bacteria of both strains. According to the results of control seeding on Endo medium, the minimum bactericidal concentration was 0.025M. Product Description popup.authors Ivakha Nadiia B Berezhnyts'ka Oleksandra S Borovyk Polina V Kozachkova Oleksandra M Orysyk Svitlana I Rohovtsov Oleksandr O Trunova Olena K Shtokvish Olgert O popup.nrat_date 2021-01-29 Close