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Information × Registration Number 0221U102288, 0117U004979 , R & D reports Title Experimental grounding of the carbonic adsorbents usage for the treatment of massive radiation lesions of external nature popup.stage_title Head Nikolaev Volodymyr G., Доктор медичних наук Registration Date 29-01-2021 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine popup.description2  Highly active granular carbon sorbents with a specific gravity of 0.09-0.12 g/ cm3 were obtained. Their use as an enterosorbent has a powerful radioprotective effect that is confirmed by inhibition of reduction of total weight in rats, decreasing the level of superoxide radicals in the liver by 1.6 times and of nitric oxide by 1.3 times, 1.3-fold reduction in brain DNA damage, as well as accelerating the restoration of pro-antioxidant balance and the number of leukocytes and lymphocytes in the blood and mitosis in the bone marrow. The sensitivity of the bovine serum albumin molecule (BSA) to external irradiation was proved by the data of the comparative analysis of the absorption and fluorescence spectra of BSA obtained before and after irradiation in the dose range of 4 - 10 Gy. Carbon microparticles exhibit radioprotective activity in vitro experiments, positively affecting the antioxidant potential of the blood under conditions of radiation exposure in doses from 4 to 10 Gy. Reepithelialization of wounds after thermal burn in rats under conditions of preliminary total irradiation at a dose of 6 Gy slows down from 21.1 ± 4.1 to 27.3 ± 5.7 days. The use of an adsorptive carbon dressing (ACD) accelerates the process by 1.3 times. ACD presence on the wound surface from the first minutes after burn injury promotes the recovery of the epidermis: the appearance of a continuous layer of basal cells with mitotic activity already on the 3rd day after injury and partial and in 40% of rats complete recovery of the epidermal layers of the skin by the 7th day. ACD has almost no effect on pathological changes in the dermis caused by irradiation. ACD application resulted in a decrease in the ratio of pro-antioxidants in hemolysates by 17.2 and 5.2% and an increase in the number of leukocytes by 35.8 and 50.2% on days 3 and 7, respectively Product Description popup.authors Bardakhivs'ka Kvitoslava I. Gerashchenko Bogdan I. Korneeva Liudmyla M. Korotich Valentyna G. Maslenny Vitalii M. Nikolaev Volodymyr G. Sarnatskaya Veronika V. Sakhno Larisa O. Sidorenko Olexii S. Snezhkova Elizaveta O. Yshko Larysa O. popup.nrat_date 2021-01-29 Close