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Information × Registration Number 0221U102290, 0118U005468 , R & D reports Title The role of remodeling markers of bone tissue in the formation of the degree of malignancy of the most common hormone-dependent tumors popup.stage_title Head Lukianova Nataliia Yu., Доктор біологічних наукChekhun Vasyl F., Доктор медичних наук Registration Date 29-01-2021 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine popup.description2  In vitro experiments on human breast and prostate cancer cells with varying degrees of malignancy and sensitivity to hormone therapy we have investigated the effect of cytostatics, hormonal drugs and growth factors on the level of expression of bone remodeling proteins. It was found that the cultivation of human breast and prostate cancer and cells with a high degree of malignancy with tamoxifen led to a significant decrease in the expression of SPARC and BMP-7 (p <0.05). A significant decrease in the expression of SPP1 and SPARC under the influence of doxorubicin was recorded in cells of the breast and prostate cancer cells of low-grade malignancy. It was determined that the effect of EGF on breast cancer cells and low-grade prostate cancer cells led to a decrease in the expression of SPP1 (p <0,05), while the incubation of high-grade prostate cancer cells with EGF also caused a decrease in BMP-7 expression (p < 0.05). Cultivation of human breast and prostate cancer cell lines with VEGF caused significant increase of the level of SPP1 expression in low-grade malignancy cells and cause a decrease in SPARC levels in high-grade malignancy cells. The obtained fundamental data indicate the need for further study of the expression of markers of bone remodeling in tumors of patients with breast and prostate cancer in order to predict the effectiveness of drug therapy. Product Description popup.authors Borikun Tetiana V. Gogol' Sergij V. Zadvornyi Taras V. Kunska Lyubov M. Lykhova Olexandra O. Lukianova Nataliia Yu. Naleskina Lesia A. Todor Igor M. Chtkhun Vasyl F. Yalovenko Tetiana M. popup.nrat_date 2021-01-29 Close