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Information × Registration Number 0221U102339, 0119U100331 , R & D reports Title Newest hybrid anti-tumor and anti-inflammatory nanocomplexes based on pyrrole and C60-fullerene: creation, characterization, pharmacodynamics and toxicological characteristics. popup.stage_title Head Rybalchenko Volodymyr K., Доктор біологічних наук Registration Date 01-02-2021 Organization Taras Shevchenko National University of Kyiv popup.description2 Object of study: 3 - {[4-chloro-1- (4-chlorobenzyl) -2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl] amino} phenyl [6,6] - phenyl-C61-butanoate (C60-MI-3OH) in combination with cold-pressed linseed oil. Subject of research: pharmacological activity, pharmacodynamics of the nanocomplex during the development of inflammatory bowel diseases and colorectal cancer. The purpose of the work is to establish anti-inflammatory and antitumor efficacy, pharmacodynamics C60-MI-3OH for correction of inflammatory diseases of the colon and concomitant pathologies. Research methods: chemical synthesis, mathematical modeling histological, biochemical, hematological, cultural, statistical analysis. It has been shown that the C60-MI-3OH nanocomplex is able to form stable bonds with the ATP-binding site of EGFR and VEGFR growth factor receptors, which may be one of the mechanisms of its biological action. C60-MI-3-OH has anti-inflammatory properties against acute inflammation of the colon, anti-tumor properties against its DMG-induced cancer, is able to partially restore the impaired liver function under these conditions, but has a negative effect on the pancreas. With increasing duration of exposure and decreasing dose of the compound, the negative effects increase.  Product Description popup.authors Byelins'ka Iryna V. Gurmach Vasyl V. Dziubenko Natalуа V. Kuznezova Galyna M. Milokhov Demyd S. Prylutsʹka Svitlana V. Repetsky Stanislav P. Стойка Ростислав Стафанович Khylya Оlga V. Zyvinska Svitlana M. Chereschyuk Iryna O. popup.nrat_date 2021-02-01 Close