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Information × Registration Number 0221U102390, 0118U007347 , R & D reports Title Biophysical mechanisms of pathological activity of neurons, caused by hypoxic-ischemic and inflammatory lesions popup.stage_title Head Korohod Serhii M, Registration Date 01-02-2021 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2  Gastrointestinal motility is based on the rhythmic activity of the interstitial cells of Cajal (ICCs) acting on smooth muscle as pacemakers. The generation of ICC rhythm is due to the characteristic mechanisms of intracellular Ca2+ regulation, which include calcium-dependent channels, pumps, and exchangers located in the plasma membrane, endoplasmic reticulum (ER), and mitochondria. Previously it has been shown that mutations, overexpression and genetic destruction of plasma membrane calcium ATPase pumps (PMCA) cause dysfunction of these and other cells. At this stage of work, the effects of overexpression and hyperactivity of PMCA on the generation of ICC pacemaker rhythm were investigated on a computer biophysical model of ICC. Product Description popup.authors Korogod Sergij M. Kulagina Iryna B. popup.nrat_date 2021-02-01 Close