Search academic texts

Information × Registration Number 0221U102445, 0120U100715 , R & D reports Title The influence of metabolites and unmodidied surface antigenic substances of the nasopharyngeal microflora on the overall and adaptive resistance of the macroorganism popup.stage_title Head Babych Yevhenii M., Доктор технічних наук Registration Date 03-02-2021 Organization State Institution "I.Mechnikov Institute of Microbiology and Immunology National Academy of Medical Sciences of Ukraine" popup.description2  The object of research - microbial cultures of associates that dominate in the microbiocenoses of the nasopharynx, metabolites of dominant associates, surface cell compounds of dominant associates; ultrasonic radiation; laboratory animals. The aim of the work is to develop adjuvants based on substances of bacterial origin from nasopharyngeal microbiocenoses to increase the overall resistance of the macroorganism and the immunogenic properties of oral and parenteral vaccines. Research methods - microbiological, biological, immunological, physicochemical, medical and statistical. Using ultrasound and the author's method of obtaining bacterial metabolites based on cultivation of producents on their own disintegrates, 4 samples of experimental antigenic preparations from C.pseudodiphtheriticum and C.xerosis were obtained. The biochemical composition was determined and effect on blood phagocytosis was tested for strains and culture of C. diphtheriaevar. gravis tox +, new, in vitro. A method of enrichment of metabolites and surface cell structures has been developed Product Description popup.authors Bilozersky Volodymir I. Babych Yevhen M Zhdamarova Larisa A. Kolpak Svitlana A. popup.nrat_date 2021-02-03 Close