Search academic texts

Information × Registration Number 0221U102548, 0120U104508 , R & D reports Title Investigate the importance of medical, biological and sociological factors in the spread of coronavirus infection among women and children in Ukraine popup.stage_title Head Podolskii Vasyl V., Доктор медичних наук Registration Date 05-02-2021 Organization State Institution "Institute of pediatrics, obstetrics and gynecology named after acad. O.M. Luk'yanova of National academy of medical sciences of Ukraine" popup.description2  As a result of research, social, medical and biological risk factors in children and women with coronavirus-19 were studied. The risk group for SARS-CoV-2 infection of children aged 13-17 from single-parent families with low financial status live in a dormitory or in unsatisfactory sanitary and hygienic conditions at home, whose mothers work and have given birth to children under 30 years. and among employees - employees with physical and mental, psycho-emotional load at work. According to the results of the work, 64 samples were obtained - Biobank for further genotyping by selected candidate genes: ACE1, IFNL4, IL6. A control group of DNA samples from the Biobank of the Laboratory of Human Genomics of the National Academy of Sciences of Ukraine (-100 samples) was formed. Genotyping by polymorphic loci was performed on the material of the Biobank of DNA samples of the control group: ACE1 (I / D) 17: 61565890; IFNL4 rs469415590 ΔG / TT, IL6 7: 22766840 -174 G / C. The analysis was performed by PCR with detection at the end point in the case of variants IFNL4rs469415590 and IL6 7: 22766840 -174 G / C followed by restriction analysis. The obtained data will be used as a control in determining the association of certain allelic variants with the severity of coronavirus disease in the studied groups of patients - children and women. Immunity was determined by serological tests, serum cytokines and avidity and antiphospholipid antibody levels in women and children with coronavirus infection. Studies have been performed to determine the mean serum levels of vitamin D in women and children and the average creatine kinase levels in women and children with coronavirus infection. Product Description popup.authors Antipkin Uriy G Kaminska Tеtiana M Livshyts Liudmyla A. Lapshin Volodymyr F Podolskyy Vasyl V Podolskyi Volodymyr V. Rudenko Svetlana A. Umanets Tetiana R. popup.nrat_date 2021-02-05 Close