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Information × Registration Number 0221U102669, 0118U004054 , R & D reports Title Immunological, virological, clinical aspects of arrhythmogenesis in young adults with idiopathic heart rhythm disorders popup.stage_title Head Volianskyi Andrii Yu, д.мед.н. Registration Date 08-02-2021 Organization State Institution "I. Mechnikov Institute of Microbiology and Immunology National Academy of Medical Sciences of Ukraine" popup.description2 Subject of the study: peripheral blood and serum of 42 patients aged 18 to 35 years with rhythm disturbances without revealed structural damage to the cardiovascular system, who are being treated and examined at the KNP "City Clinical Hospital No. 8" CHC. Research methods: immunological, serological, clinical, statistical. The identified markers of the inflammatory process in combination with markers of persistent herpesvirus infection indicate that in patients with rhythm disturbances, despite the absence of clear clinical and instrumental data, there are immune-mediated ultrastructural inflammatory changes in the myocardium. It was found that the basis of non-coronary ventricular rhythm disturbances in the form of ventricular extrasystole can be ectopic foci of excitation caused by a latent inflammatory process in the myocardium.With an increase in TNF-a content over 14.9 pg / ml, the risk of developing threatening ventricular arrhythmias increases 2.5 times, and with an increase in IL-6 concentration from 20 to 24 pg / ml, the risk of ventricular tachycardia paroxysm increases 4 times. Detection of autoantibody titers at a level of =1: 40 in more than 60% of patients with idiopathic rhythm disturbances, which is almost 5 times more often in the control group, indicates immune-mediated ultrastructural changes in the myocardium and, if the titer increases more than 1 160, is regarded as an unfavorable prognostic factor the progression of ectopic activity of the heart, despite the absence of clear clinical and instrumental data on cardiovascular pathology.The most unfavorable combination is the presence of three or more herpes viruses in the blood at the same time, an increase in the level of TNF-a and IL-6 to 24 pg / ml and 30 pg / ml, respectively, and titers to sarcolemous structures more than 1 120. Product Description popup.authors Davydenko Maryna B. Kashpur Nataliia V. Klysa Olena O Klysa Tetiana L Peremot Svitlana D. Peremot Yakiv O Smilianska Maja V popup.nrat_date 2021-02-08 Close