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Information × Registration Number 0221U102788, 0117U004730 , R & D reports Title Scientific justification and optimization of the management of patients with ischemic heart disease and arterial hypertension on the background of comorbid conditions popup.stage_title Head Potabashniy Valeriy A, Доктор медичних наук Registration Date 10-02-2021 Organization State institution "Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine" popup.description2  Purpose: to optimize the diagnosis and approaches to the treatment of coronary heart disease and hypertension in patients with comorbid conditions (COPD, cerebrovascular disorders, abdominal obesity, gout) based on the study of the clinical course, structural and functional state of the cardiovascular system and metabolic disorders using modern research methods. Object of research: hypertension, COPD, gout, comorbidity. Subject of research: cardiovascular risk, features of the clinical course of hypertension in combination with gout, purine and lipid metabolism, structural and functional state of the left ventricle, treatment of patients with hypertension and comorbid COPD, gout, quality of life, commitment to treatment. Research methods: general clinical examination, quality of life and health questionnaires, PGA, determination of pain intensity according to VAS, adherence to Moriski-Green treatment (4-item MARS); laboratory (blood test, urine test, blood lipids, blood glucose, blood electrolytes, blood creatinine, urea, uric acid (UA) of blood, UA of urine, UA clearance, hsCRP, ferritin, direct and indirect bilirubin, liver transaminases, the calculated glomerular filtration rate according to the formula CKD-EPI). Instrumental research methods: electrocardiography; transthoracic doppler echocardiography; ultrasound of extracranial vessels, kidneys, joints, outpatient ECG and blood pressure monitoring; spirometry; pulse oximetry; 6-minute test with walking, X-ray examination of the chest and joints. Statistical methods: descriptive, analytical, parametric and nonparametric. The essence of the study. Based on ROC analysis of SpO2 at the cut-off point ≤94.9% (sensitivity was 95.5% and specificity - 77.1%, AUC = 0.91; 95% CI 0.81-0.96; p <0.001) the prognostic effect of hypoxemia on LV systolic dysfunction has been established. An integrated cardiorespiratory test has been developed to evaluate the effectiveness of treatment of patients with hypertension and comorbid Product Description popup.authors Burtniak Tetiana Z Vasylenko Anatolij M Kniazieva Olena V Kuzmina Hanna P Lazarenko Olha M Markova Olena Ya Potabashniy Valeriy A Fesenko Volodymyr I popup.nrat_date 2021-02-10 Close