Search academic texts

Information × Registration Number 0221U103204, 0118U002207 , R & D reports Title Development of 2D materials and "smart" sensors for medical and biological purposes on their basis.Section 2. Synthesis of 2D materials based on BN and WS2 nanoparticles for biomedical applications popup.stage_title Head Posudievsky Oleg Yu., Доктор хімічних наук Registration Date 16-02-2021 Organization L. V. Pisarzhevskii Institute Of Physical Chemistry of The National Academy of Sciences of Ukraine popup.description2  The methods for modifying layered tungsten disulfide (WS2) nitrogen and sulfur-containing functional groups by means of mechanochemical nanostructuring in the presence of ammonium carbonate (2D-WS2 (N)) or ammonium thiosulfate (2D-WS2 (N,S)) at 150 ° C have been developed. It was found that ultrasonic disintegration of modified samples of 2D-WS2 in water leads to the formation of mainly monolayer nanoparticles of tungsten disulfide with the crystal structure of WS2. It is shown that the use of ammonium carbonate or ammonium thiosulfate can increase the degree of functionalization of WS2 and promotes its more efficient liquid-phase exfoliation in water to obtain more concentrated aqueous dispersions (0.2, 0.5 and 0.7 mg / ml for 2D-WS2, 2D-WS2 (N ) and 2D-WS2 (N, S), respectively), which is important for the use of such materials in biomedical sensors. It was found that the effect of 2D-WS2 nanoparticles on the formation of amyloid fibrils depends on the pH of the medium and protein concentration, namely: in a strongly acidic environment (pH = 2.0) in concentrated protein solutions (20 mg / ml) the introduction of 2D-WS2 nanoparticles during incubation to increase the number of amyloid fibrils, whereas in a highly alkaline medium (pH = 11.5), the addition of 2D-WS2 during incubation leads to a decrease in amyloid fibrils, regardless of protein concentration. Product Description popup.authors Konochuk Natalia V. Posudievsky Oleg Yu. popup.nrat_date 2021-02-16 Close