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Registration Number

0221U103243, 0118U000266 , R & D reports

Title

Development of theoretical foundations for the creation of promising thiosulfonate means for the protection of agroproducts from microorganisms - producers of mycotoxins.

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Head

Lubenets Vira I., Доктор хімічних наук

Registration Date

17-02-2021

Organization

Lviv Polytechnic National University

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Ways and methods for obtaining promising fungicidal substances of thiosulfonate structure have been developed and known synthesis methods have been adapted to obtain new thiosulfonates of asymmetric structure. Alkyl, alkyl-functionalized, aryl, heterocyclic esters of aliphatic and aromatic thiosulfonic acids have been synthesized. Their physicochemical properties were investigated and computer screening of the predicted biological activity was performed according to the PASS program. The microbiological synthesis of laboratory bioPAR samples by different producers was carried out, their physicochemical properties in relation to their influence on the properties of thiosulfonate compounds were studied. It has been shown that phenyl and 4-methoxyphenyl esters of methane and ethantiosulfonic acids show high activity against all studied fungal strains in in vitro experiments, surpassing in some cases the action of known fungicides (zineb, captan, figon). Methods for obtaining new stable solubilized water-soluble compositions of promising thiosulfonates with bioPAR and synthetic surfactant TVIN-80 have been developed. Using the concept of green chemistry, a promising reagent γ-crotonolactone with a wide range of biological effects was synthesized, which was used to modify thiosulfonates in order to obtain new water-soluble esters of thiosulfonic acids. The effect of ethylthiosulfanilate administered to rats for 14 days was studied and a decrease in the intensity of the increase in the content of lipid hydroperoxides in the liver caused by the action of Cr (VI) was found. The use of ethylthiosulfanilate has been shown to prevent depletion of reduced glutathione (GSH) under oxidative stress caused by potassium dichromate and to promote the accumulation of cellular GSH in the liver of rats. Thiosulfonates with a propyl moiety in aqueous and water-emulsion solutions can be used to treat grain before storage to protect against damage by phytopathogenic fungi of the species  

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Banya Andriy R
Havrylyak Victoria V
Karpenko Olena V
Komarovska-Porokhniavets Olena Z
Koretskaya Natalia I
Monka Natalia Ya.
Pylypets Andriy Z
Pokynbroda Tatiana Ya.
Stadnytska Natalia Ye
Khomitska Halyna M
Yaremkevich Olena S

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2021-02-16