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Information × Registration Number 0221U103280, 0120U105413 , R & D reports Title To study the molecular and genetic antibiotic resistance markers of epizootologically and epidemiologically Salmonella spp. valuable species to beta-lactams and fluoroquinolones. popup.stage_title Head Herilovich Anton Р., д.вет.н. Registration Date 17-02-2021 Organization National Scientific Center Institute of Experimental and Clinical Medicine popup.description2  The aim of the work is to create a methodology for identifying the genetic determinants of bacteria antibiotic resistance of the Salmonella genus to beta-lactams and fluoroquinolones using molecular genetic methods. Replenishment of the pathogen collection with bacteria isolates of the Salmonella genus, establishment of the genotypic determinants of resistance to beta-lactams and fluoroquinolones. Research methods - bioinformatics, bacteriological, molecular genetics. A set of studies aimed at establishing the presence and prevalence of resistance factors to beta-lactams and fluoroquinolones antibacterial drugs of the bacteria from Salmonella spp. genus was provided. Genotypic markers of Salmonella spp. resistance to groups of drugs detailed above have been established. Genotypic and phenotypic resistance profiles were determined. The presence of stable mobile genomic structures (integrons, genomic islands), which are carriers of cassette antibiotic resistance genes in salmonellas was established. A methodology for detecting the resistant forms of the Salmonella genus bacteria to fluoroquinolones and beta-lactams using molecular genetic methods has been developed. The collection of salmonella is supplemented by 133 field samples of various origin. Product Description popup.authors Arefiev Vasyl' L Biloivan Oleksandr V Zlenko Oksana B. Lymanska Olga Yu. Mayboroda Olga E Muzyka Denys V. Rudova Nataliia H Rula Oleksandr M. Solodjankin Oleksij S. popup.nrat_date 2021-02-17 Close