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Information × Registration Number 0221U103304, 0119U000226 , R & D reports Title Rational design of S,N-modified aminothiols as potential anti-radiation agents. popup.stage_title Head Kornet Maryna M., Кандидат біологічних наук Registration Date 18-02-2021 Organization Zaporizhzhia National University popup.description2 The object of the scientific work: potential radioprotectors – S-heterylmodified derivatives of endogenous thiols. The purpose of the research work is to develop promising substances with antioxidant and potential radioprotective properties capable of blocking and / or reducing the effects of radiation. During the implementation of this project, all the results scientifically substantiated by the available primary materials, preserved research protocols, photography, the correctness of the results obtained is provided with a sufficient sample and analyzed by statistical methods of analysis. Useful practical and methodological developments are developed and tested methods of synthesis, including both classical methods and tools of modern organic chemistry such as microwave synthesis, spectral and physicochemical analysis of newly synthesized compounds, and the characteristics for resynthesis derivatives have been added; results of primary biological screening for compounds with potential radioprotective properties. As a result of the second stage of scientific work, the following results were obtained: 1. New and resynthesis S, N-modified aminothiols – 25 compounds with certain physicochemical constants and spectral characteristics. 2. The results of primary screening studies of antiradical activity (in vitro) and toxicity (in vivo) were obtained. 3. Three connections were found as hit-compound.   Product Description popup.authors Aminov Ruslan F Balyura Vladislav V Bekasova Oleksandra F Klimova Olena O Krivko Alevtyna I popup.nrat_date 2021-02-18 Close