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Information × Registration Number 0221U103367, 0117U005431 , R & D reports Title Synthesis of new potentially active compounds based on urea and thiourea derivatives, prediction their bioactivity. popup.stage_title Head Bohatyrova Olena V, Registration Date 18-02-2021 Organization Donetsk National Medical University popup.description2 Heterocyclic сompounds with fragment «six-member cycle – atom of nitrogen – five-member cycle» often show significantly biological activity. The kernel of 1,2,4-triazole is isosteric to five-member heterocycles mentioned, and this biological activity will be likely to be shown in the series of 3-(arylamino)-1,2,4-triazole. The work shows that reactions of acylthioureas with hydrazines lead to substituted 3-(arylamino)-1,2,4-triazoles. Interaction of aryl(pyridyl) substituted 3-amino-1,2,4-triazoles with acylating agents were studied. The structures of all products have been determined; and their structural features have been discussed. Received substances be able to multiple water-based connections and π ... π-stacking, that also increases the probability of biological activity. Product Description popup.authors popup.nrat_date 2021-02-18 Close