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Information × Registration Number 0221U103430, 0119U101119 , R & D reports Title Molecular-genetic and morphological features of bone tissue repair using functional protective coatings of implantation materials popup.stage_title Head Loskutov Oleksandr Ye., Доктор медичних наук Registration Date 20-02-2021 Organization State institution "Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine" popup.description2  At the current stage of work, intrafemoral implantation of titanium rods with six types of coating was performed on 65 Wistar rats (4 and 8 weeks of exposure). The technique of vital coloring of bone tissue with fluorochromes was tested to further determine the growth rate of bone matrix. Samples of non-decalcified bone tissue with a preserved metal implant were infiltrated into polymethyl methacrylate resin with its subsequent polymerization; Histological examination of demineralized bone tissue with Mason-Goldner trichrome staining was performed to study the cell-matrix interaction along with immunohistochemical evaluation of bone remodeling biomarkers expression (osteocalcin, osteopontin, osteoprotegerin, osterix, runx2) Product Description popup.authors Bozhko Anton H. Bondarenko Nina S. Bondarenko Olexandr O. Domanskij Andriy M. Yakushev Serhiy O popup.nrat_date 2021-02-20 Close