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Information × Registration Number 0221U103583, 0118U007343 , R & D reports Title Molecular, genetic and pharmacological agents of influence on cellular mechanisms of neurological disorders. popup.stage_title Head Kryshtal Oleg O., Доктор біологічних наук Registration Date 22-02-2021 Organization Bogomolets Institute of Physiology popup.description2  The technique of the 4-aminopyridine model of temporal lobe epilepsy was optimized concerning the parameters of the perfusion rate of the experimental sample and the stability of its oxygenation level. A system of 24h telemetric monitoring of experimental animals with constant registration of intrahippocampal EEG based on specially developed devices has been implemented. Hypoxia leads to K+-dependent (due to increased K+input) and K+-independent disconnection of the respiratory chain and inhibition of ATP synthesis. Hematopoietic stem cells generate exosomes that contain active proteasomes but not caspases. Nitrosoglutathione or its degradation product (s) partially inhibits the activity of Na+/K+-ATPase and Ca2+-ATPase in the plasma membrane of rat brain cortex cells. In this case, the inhibition of Ca2+-ATPase of the plasma membrane is not associated with changes in its sensitivity to Ca2+. Product Description popup.authors Isaiev Dmytro S. Maksymyuk Oleksandr P. Prudnikov Ihor M. Storozhuk Maksim V. Cherninsky Andrij O. Chyzhmakov Ihor V. popup.nrat_date 2021-02-22 Close