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Information × Registration Number 0221U104063, 0119U102720 , R & D reports Title Controlled association of plasmonic nanoparticles in the presence of biomolecules as a method for creating sensor systems and theranostics popup.stage_title Head Mukha Yuliia P., Registration Date 01-03-2021 Organization Chuiko Institute of Surface Chemistry of NAS of Ukraine popup.description2 The possibility of using the nanosized noble metals as sensors for the detection of a human prostate cancer marker, namely polyamine spermine (spn), was investigated. The changes in optical signal in absorption spectra of the nanoparticle/polyamine system was demonstrated, namely the shift of the position of the localized surface plasmon resonance (LPPR) band of the metal and decrease of its intensity in the maximum, and/or the appearance of a new band in the long wavelength region. The new band is the result of superposition and amplification of electric fields at the nanoparticles (NPs) interaction points, which arise due to the formation of associates (aggregates) of nanoparticles interconnected through the bridging polyamine. It was shown, that with an increase of the concentration of polyamine spn from 9 to 900 nm in Au NPs/spn systems noticeable changes in the optical signal occured. In particular, starting from the spn concentration of 450 nm, a new LPPR band arrears (except the main band placed at λmax1 = 519 nm) with a pronounced maximum in the region of λmax2 = 654-672 nm, its intensity reaches the plateau after a concentration of 750 nm. A calibration curve was built to determine the spn content in the studied system. The possibility of selective detection of spermine in the presence of ultrahigh concentrations of spermidine (spd) using colloidal solutions of nanosized gold, stabilized with sodium citrate, was shown, that can be used to determine spermine in biological fluids for differential diagnosis/prognosis of prostate cancer. A method for concentrating colloidal solutions of gold and silver nanoparticles using pluronic F68 as an additional stabilizing agent was developed. It allows to increase the metal content in colloids up to 0.4-0.8 mg/ml, while the particles remain nanosized and stable over time, maintaining the characteristic optical properties of metals - the position of the maximum of the plasmon resonance band and its intensity. Product Description popup.authors Mukha Iuliia P. Pylypchuk Yevgen V. popup.nrat_date 2021-03-01 Close