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Registration Number

0221U104306, 0119U100320 , R & D reports

Title

Selectivity in the reactions of carbo-, heterocyclic and functionalization for medical chemistry and sustainable development.

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Head

Voitenko Zoia V., Доктор хімічних наук

Registration Date

13-03-2021

Organization

Taras Shevchenko National University of Kyiv

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Object of research: heterocyclic compounds, incl. nitrogen-containing (isoindoles, condensed isoindoles, their heteroanalogues, quinazolones, their heteroanalogues, pyridine-containing amino acids, maleic and succinimides, etc.) and oxygen-containing (chromones and their derivatives, condensed oxygen-containing systems, etc.) with one or two. Purpose: development of modern selective and preparative synthetic approaches to obtaining new molecules of carbo- and heterocyclic nature, as well as their further controlled functionalization for medical chemistry and sustainable development. Research methods: study by spectral and computer methods of influence of various factors that determine the selectivity of the studied reactions of carbo-, heterocyclization and functionalization (catalyst, solvent, temperature, electronic nature of substituents, steric factors, etc.), study of fluorescence spectra. The influence of catalytic conditions and asymmetric induction on the course of the cycloaddition reaction is established. The cyclization reaction of aminoiminoisoindole with substituted ortho-aminobenzoic acids, as well as their heteroanalogues, has been studied. The peculiarities of the structure and physicochemical properties of the obtained compounds are studied. Modification of chromanone derivatives is carried out, structures and properties of reaction products are investigated. A selective preparative method for the synthesis of oxadiazoles of the chromanon series has been developed. Synthetic analogues of natural compounds with amino acid residues have been modified. Fluorescent probes were synthesized - derivatives of 3-hydroxyflavone, which are able to form an increased, compared to known analogues, the number of hydrogen bonds, stacking interactions and dipoldipole interactions, in particular modified in the 4 'position aminoflavonols:

Product Description

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Yehorova Tetyana V.
Ivon Yevhen М.
Biitseva Angelina V.
Bugera Oleksandra I.
Kysil Аndriy І.
Krykun Serhii O.
Levkov Igor V.
Lyubchuk Tetyana V.
Zapko Magdalina D.
Shylin Sergiy V.

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2021-03-17