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Information × Registration Number 0221U104375, 0118U001214 , R & D reports Title To study the importance of genetic factors and external influences on the development and progression of microcirculatory complications of type 2 diabetes mellitus popup.stage_title Head Natrus Larysa V., Доктор медичних наук Registration Date 15-03-2021 Organization Bogomolets National Medical University popup.description2 The obtained data provided a basis to form a concept about differences in the pathogenic mechanisms of DR progression in patients with different PPARγ genotype. In carriers of wild PPARγ genotype, DR as a complication of DM II occurs as a result of chronic inflammation due to PPARγ -dependent gene transcription, expression of enzymes that oxidize arachidonic FA, synthesis of metabolites that affect the endothelium state, platelets, blood coagulation, etc. In patients with polymorphism, PPARγ-dependent gene transcription is inhibited and FAs are utilized in the cell by other L-FABP mechanisms, leading to activation of direct peroxisome oxidation and deepening of inflammation due to oxidative stress.   Product Description popup.authors popup.nrat_date 2021-03-17 Close