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Information × Registration Number 0221U104584, 0118U001275 , R & D reports Title Increase effectivity of diagnostics and treatment pathology of the retina and nervus opticus in diabetes. popup.stage_title Head Serdiuk Valerii M., Доктор медичних наук Registration Date 01-04-2021 Organization State institution "Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine" popup.description2 The research work report: 158 pages, 27 figures, 36 tables, 295 literary sources. The object of study - animals with experimental diabetic retinopathy with diabetes mellitus and patients with diabetic retinopathy in type 2 diabetes mellitus. The aim of the work is to investigate the diagnostic significance of the study of markers of endothelial dysfunction, proinflammatory chemokines, adipose tissue hormones in patients with diabetic retinopathy, to increase the effectiveness of treatment of retinal and optic nerve diseases in type 2 diabetes mellitus by scientific development of optimal treatment schemes with L-arginine. Research methods - clinical methods (visometry, ophthalmoscopy, biomicroscopy), biochemical methods (study of the activity of lysosomal enzymes, enzymes of lipid peroxidation and redox enzymes in tears and blood), statistical processing of results. Equipment - personal computers, laboratory equipment. The novelty of the study – it was selected the optimal dose of complex administration of alloxan and fructose for the reproduction of experimental DR for diabetes with 100% survival of animals; the comparative characteristics of changes of an eyeball at the modified experimental alloxan models of a diabetes mellitus of both 1st, and 2nd type are defined; the effectiveness of the corrective action of L-arginine on the development of diabetic retinopathy in the experimental conditions was revealed; identified features of the development of mild non-proliferative DR on the background of treatment with L-arginine, based on clinical and biochemical data; proposed additional features of the classification of microangiopathies by ETDRS, which are based on the dynamics of the content of markers of endothelial dysfunction: Willebrand factor, endothelin-1 and eNOS activity; the informativeness of determination of markers of endothelial adhesive dysfunction and endothelial damage in the assessment of DRP progression was supplemented; scientific data on  Product Description popup.authors Ishchenko Vladyslav A Alifanov Ihor S Drozdov Volodymyr O Klopotska Natalia H Pylypenko Liudmyla Yu Semenko Volodymyr V popup.nrat_date 2021-04-01 Close