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Information × Registration Number 0221U104957, 0118U003730 , R & D reports Title Optimize morphological diagnostics of lymphoproliferative processes and metastatic lesions of lymph nodes using a complex of modern cytological and histological research methods. popup.stage_title Head Bolgova Lidiya S., Доктор медичних наук Registration Date 27-04-2021 Organization National Cancer Institute popup.description2 The object of the study - 278 patients with pathological lymph nodes, their morphological drugs in comparison with cellular data. The subject of research - histological, histochemical, cytological, cytochemical and cytogenetic preparations of patients with lymph node diseases. Purpose: to optimize the morphological diagnosis of lymphoproliferative processes and metastatic lymph node lesions using a set of modern cytological and histological research methods. Cytogenetic study was performed by determining the main morphofunctional types of nucleoli by assessing the quantitative and qualitative composition of acidic non-histone proteins (nuclear regions of chromosomes) to differentiate benign and malignant lymphoproliferative processes, the degree of malignancy and determine the prognosis. Cytomorphological features and possibilities of immunocytochemical researches for differential diagnosis of primary and metastatic processes in lymph nodes are studied. The proportion of individual immunohistochemical markers for lymphoma typing was determined. The nature of the microenvironment of tumor foci in different types of lymphomas has been studied. The peculiarities of lymphoma response to treatment depending on their immunophenotype and microenvironment are determined. Product Description popup.authors Makhortova Maria G. Tuganova Tamara M. popup.nrat_date 2021-04-27 Close