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Registration Number

0221U105058, 0116U003829 , R & D reports

Title

Influence of hypo- and hypercapnia on the cardiovascular functional state of man

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Head

Kovalenko Stanislav O,

Registration Date

31-05-2021

Organization

Bohdan Khmelnytsky National University of Cherkasy

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It is found that breathing at a rate of 30 cycles per minute for 10 minutes leads to a significant decrease in the level of carbon (IV) oxide in the alveolar air on average from 40.12 ± 0.361 mm Hg up to 18.59 ± 0.542 mm Hg with no complete recovery for 40 minutes. The reactivity of PetCO2 under the influence and during the recovery period has a wide range of individual manifestations. The latter is due to the baseline level of this indicator, which is an individual-typological characteristic of the human body. During 10-minute hyperventilation with a frequency of 30 cycles per minute, there is a decrease in the duration of R-R intervals and total peripheral vascular resistance, and an increase in cardiac index. During the recovery period, only an increase in the duration of R-R intervals to a maximum of 20 minutes was reliable. It is confirmed that the initial tone of the autonomic nervous system modulates changes in human haemodynamics in respiratory hypocapnia and affects the features of long-term changes after cessation of such influence: vagotonics and normotonics are characterized by optimal haemodynamic parameters, since the increase in heart rate during hypocapnia is accompanied by higher rates of shock and cardiac indices, along with a lower index of myocardial tension. Vagotonics are found to have higher level of PetCO2 than other the subjects. The reactivity of haemodynamics depends on the initial stress of carbon (IV) oxide in the alveolar air: the subjects with its medium and high levels have higher reactivity than in the group with low baseline PetCO2. The subjects with a medium baseline PetCO2 level have more effective haemodynamic changes, as hypocapnia has increased cardiac output due to the increased volumetric ejection velocity and stroke index, along with a decrease in stress period and myocardial stress index.

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Zavhorodnia Viktoriia Anatoliivna
Kovalenko Stanislav O.
Kudiy Ludmila Ivanovna
Rybalko Alevtyna Volodymyrivna

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2021-05-31