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Information × Registration Number 0221U105241, 0120U101281 , R & D reports Title New molecular determinants of intracellular and intercellular signaling in normal and pathology popup.stage_title Head Kryshtal Oleg O., Доктор біологічних наук Registration Date 17-06-2021 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2  The studies on the project were fulfilled in several planned areas: Study of the role of ASIC and GABA channels in epileptic disorders; Establishing the fact whether the role of calcium ions is primary in the development of Alzheimer's disease; Characterization of mono- and polysynaptic primary inputs to neurons of plate X, as well as descending pathways that innervate and regulate neurons of this lamina; Study of structural and functional changes of nerve cells in the conditions of experimental ischemia of the brain and study of the effect of neuroprotective agents on structural plasticity in this pathology; Simulation of STZ-induced diabetes in rats and comparison of functional responses of detrusor preparations of normal and diabetic rats to exogenous TRPV1 agonists and antagonists. Conducting immunohistochemical studies of detrusor drugs of normal and diabetic rats for changes in the expression and localization of TRPV1-channel; Study of the work of calcium channels and intracellular mechanisms of calcium homeostasis under conditions of both experimentally induced pathological conditions and using models of neuronal damage; The effect of artificial hyperglycemia on calcium signaling was studied on ganglion cells of the intact retina of an adult rat, and the aim of detecting calcium-dependent mechanisms of hypoxia-induced plasticity of neurotransmission was investigated in the culture of retinal ganglion cells in the optic nerve model; Finding out the reason for changes in the sensitivity of the protein complex that forms the pore to Ca2 + and the involvement of mitochondrial Ca2 + dependent enzymes in these changes Product Description popup.authors Yehorova Olena V. Abramovych Tetyana I. Akopova Olga V. Andrianov Yaroslav Ye. Bilan Pavlo V. Blashkiv Taras V. Bulhakova Nataliya V. Veselovsky Mykola S. Voznesenska Tetiana U. Voitenko Nana V. Ganzha Vita V Gonchar Olga O. Gorbachenko Vasyl А. Gorkovenko Andriy V. Goshovska Julia V Julia V. Dovgalets Halyna V. Dosenko Viktor Y. Drachuk Kostyantyn О. Drevitskaya Tatjana I. Dromaretsky Andriy V. Zavodovsky Danylo O. Kaleynikova Oksana M. Kolomiets Iryna I Korkach Julia P. Korneev Valentin V. Kostyukov Oleksandr Ivanovich Kostiukov Oleksandr Ivanovich Kotyk Olena A. Kotlyarova Anna-Malhozhata B. Krotov Volodymyr V. Kuliyeva Yevheniya M. Levashov Mykhaylo І. Litovka Irina G. Legedza Oleksiy V. Lukyanets Olena O. Lunko Olesya V. Lyubanova Olga P. Magura Igor S. Maznichenko Andriy V. Maksymyuk Oleksandr P Mankovska Iryna M. Maslov Vitaliy Y. Mys Lidiya A. Nagibin Vasyl S. Nasibyan Lilit S. Pashevin Denis О. Petrushenko Mariya O. Plyuta Iryna M. Portnichenko Alla G. Portnichenko Volodymyr I. Portnychenko Heorhiy V. Prudnikov Igor M. Pushchyna Yevheniya V. Rozova Kateryna V Rozumna Nataliya M. Sagach Vadim F. Safonov Serhiy L. Скибо Галина Григорівна Sotkis Anna V. Sribna Valentyna O. Strutynska Natalia A. Strutynskyi Ruslan B. Tumanovska Lesia V. Filipov Igor B. Tsapenko Petro K. Tsuhorka Oleksandr M. Tsupikov Oleg M. Chaka Olena G. Sharopov Bizhan R. Shysh Anzhela M. Shkril Vyacheslav M. Shuba Yaroslav M. Yanko Roman V. Yanchiy Roman I. popup.nrat_date 2021-06-17 Close