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Information × Registration Number 0221U105447, 0120U105155 , R & D reports Title Investigation of physicochemical properties of synthesized preparations of simple metal nanoparticles with different stabilizers. Development of theoretical models of field interaction of nanoparticles with extracellular virus taking into account the stabilizer and concentration of nanoparticles and features of virus structure. popup.stage_title Етап 1 Head Lysenko Volodymyr S., Registration Date 07-07-2021 Organization VE Lashkarev Institute of Semiconductor Physics of the National Academy of Sciences of Ukraine popup.description2  The object of study - metal nanoparticles obtained with various stabilizers, viruses. The aim of the work is to determine the effect of stabilizers on the antiviral action of nanoparticles Research method - optical studies, theoretical studies of the interaction between nanoparticles and viruses The urgency of the work is due to today's challenges, in particular the SARS-Cov-2 pandemic, which encourages us to search for new classes of antiviral substances aimed at substances with multifunctional action, which include metal nanoparticles. It was found that the use of various stabilizers - sodium citrate and triptofan have little effect on the antiviral effect of nanoparticle preparations. Experiments conducted on H1N1 influenza viruses, adenoviruses and Epstein-Barr viruses confirmed the authors' idea of ​​the predominantly field nature of the interaction between viruses and nanoparticles. Theoretical analysis of the interaction between nanoparticles and viruses, conducted on the basis of the model proposed by the authors, suggested that the difference in the action of nanoparticles with different stabilizers is caused by the influence of the nanoparticle shell (stabilizer) on nanoparticle aggregation processes. And as it follows from the near-field mechanism of action of nanoparticles on viruses (formation of inhomogeneous local field on the surface of the virus due to the effect of local field enhancement and the emergence of ponderomotor forces acting on the virus shell) - larger nanoparticles (resulting from coagulation of nanoparticles) have worse local field enhancement effect , ie have worse action on the suppression of infectious activity of viruses. Product Description popup.authors popup.nrat_date 2021-07-07 Close