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Registration Number

0221U105496, 0118U007352 , R & D reports

Title

Investigation of the role of hydrogen sulfide and glutathione systems in cardiovascular reactivity in the norm and pathology

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Head

Sahach Vadym Fedorovych,

Registration Date

14-07-2021

Organization

Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine

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 The decrease in glutathione content шт. myocardium occurs not only due to the action of its inhibitor BSO but also in ischemia-reperfusion which can be prevented by prior administration of a combination of PAG and L-cysteine compounds. This combination showed a cardioprotective effect in the model of focal cerebral ischemia preventing impaired pumping and diastolic function of the myocardium. The glutathione containing drug restored the synthesis of hydrogen sulfide in the cardiac mitochondria, reduced oxidative stress, reduced sensitivity of MPT pore opening in old rats. In addition, microinjections of glutathione into the dorsomedial nuclei of the medulla oblongata of rats dose-dependently reduced systemic blood pressure which was abolished by inhibition of one of the enzymes of hydrogen sulfide synthesis - 3-MPST confirming the relationship between glutathione, hydrogen sulfide and their effects on blood vessels.

Product Description

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Ilina Tetiana A.
Akopova Olga V.
Bondarenko Oleksandr I.
Goshovska Julia V Julia V.
Dmytrenko Olga V.
Dorofeyeva Natalia О.
Drachuk Kostyantyn О.
Kop´yak Bohdan S.
Korkach Yulia P.
Luchkova Alina Y.
Mys Lidiya A.
Okhay Iryna Y.
Strutynska Natalia A.
Fedichkina Raisa A Raisa A.

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2021-07-14