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Information × Registration Number 0221U105680, 0118U007353 , R & D reports Title Changes in functional characteristics of neurons and interneuronal interaction in experimental models of damage popup.stage_title Head Veselovskyi Mykola S., Доктор біологічних наук Registration Date 09-08-2021 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2 Voltage-gated ion channels types that are involved in noradrenergic modulation of the electrical activity of trigemental ganglion neurons (GTN) have been identified. The long-term effect of neurotrophin of nerve tissue growth factor (NGFT) on voltage-gated calcium channels was studied. It was determined the role of norepinephrine-induced modulation of calcium currents. It was registered an increase of norepinephrine effect on Calcium current in neurons that was cultured in the presence of NGFT. It was found that the average of decay time constant excitatory postsynaptic potential of rats with MD was 15% higher than in control rats. However, the amplitudes of excitatory postsynaptic potentials of SCG neurons and blocking effect of hexamethonium 30 days after streptozotocin injection didn’t different significally with control rats. This may indicate specific functional disorders associated with nicotinic cholinergic receptors of SCG neurons under steadily elevated blood glucose levels in rats.  Product Description popup.authors Voytenko Serhiy V. Gotsulyak Yaroslav М. Dumanska Hanna V. Kuznetsov Kyrylo І. Purnyn Olena E. Remizov Igor M. Ryhalsky Oleg V. Telka Maria V. Fedulova Svitlana А. Shypshyna Mariia S. popup.nrat_date 2021-08-09 Close