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Information × Registration Number 0221U105894, 0118U000945 , R & D reports Title Optimization of diagnostics and prevention of chronization of microbial-inflammatory diseases of urinary system and progression of nephropathies in children managed by the interaction of macro- and microorganisms popup.stage_title Head Makieieva Nataliia Ivanivna, Доктор медичних наук Registration Date 07-09-2021 Organization Kharkov State Medical University popup.description2  The etiological features of children with pyelonephritis with the simultaneous establishment of factors of pathogenicity and virulence of pyelonephritis pathogens; detection of sensitivity of microorganisms to antimicrobial drugs to determine the mechanisms of resistance for the development of diagnostic criteria. Based on microbiological analysis, criteria for the development of methods for rapid diagnosis of antibiotic sensitivity of etiological factors of pyelonephritis in children in the form of biofilms, assessment of the immune response with in-depth study of the cooperative interaction of cellular and humoral immune system, neutrophil traps. The method of inhibition of enzymes of pathogenicity, toxin formation, formation of biofilms of microorganisms, pathogens of pyelonephritis and research of immune protection activity with establishment of ability to formation of neutrophilic extracellular traps is determined, which allows to improve methods of antimicrobial and immunomodulatory therapy of pyelonephritis in children. Microbiologically substantiated and improved approaches and methods of application of antimicrobial drugs taking into account research of communicative properties of microorganisms Product Description popup.authors Golovachova Viktoriia Olexandrovna Dubovyk Olena Sergiivna Mishyna Maryna Mitrofanivna Morozova Olga O. Pryima Iulia S. popup.nrat_date 2021-09-07 Close